Project objectives

Development of higher order methods for accurate measurements of infectious agents in clinical samples

The main aim of this workpackage is to develop methods of higher order for accurate measurements of infectious agents in clinical samples and assignment of traceable values to reference materials and to assess their performance and measurement uncertainty. The research will investigate: Selection of model systems for infectious agent Selection and evaluation of nucleic acid …

View page »

Assessment of emerging screening methodologies for surveillance and monitoring of disease load and antibiotic resistance

This workpackage aims to investigate the validation and standardisation requirements to support the application of new and emerging molecular approaches for the surveillance, monitoring of infectious disease load, and detection of antimicrobial resistance mutations. The last decade has seen an increase in the number of higher throughput and/or more extensive analytical technologies that offer unique …

View page »

Assessment of emerging methodologies for rapid, near patient detection of infectious agents

The aim of this workpackage is to assess performance characteristics and to identify the measurement support needed to characterise/validate selected new instrumentation, assays and kits dedicated for rapid and / or near patient detection of infectious agents. In particular, novel rapid isothermal amplification approaches for nucleic acid amplification and detection have shown promise in this …

View page »

Development of a metrology framework

Development of a metrology framework (reference systems) enabling improved performance assessment and monitoring of end user molecular diagnostic methods for the detection of infectious diseases The aim of this work package is to assess the potential of the methods developed under WP1 for establishing a reference system. Reference systems serve as anchor points over space …

View page »

Creating impact

The primary aim of INFECT-MET is to begin to address the issue of developing a metrological framework for molecular measurements of infectious agents, which aims to reconcile issues of metrology, traceability and the clinical and WHO (IU) community that measurements must be relevant and commutable. Knowledge brokerage will take place mainly at three levels: Two …

View page »

Project management and coordination

LGC will act as project co-ordinator, ensuring that the project is effectively completed to time and budget. Management and reporting of the project will be in accordance with EMRP guidelines, with the co-ordinator having overall responsibility for: Overall responsibility for the technical direction of the project, pro-actively assessing progress and taking action where necessary Financial …

View page »