The Molecular Bacterial Load Assay Replaces Solid Culture for Measuring Early Bactericidal Response to Antituberculosis Treatment

Isobella Honeyborne, Bariki Mtafya, Patrick P. J. Phillips, Michael Hoelscher, Elias N. Ntinginya, Anke Kohlenberg, Andrea Rachow, Gabriel Rojas-Ponce, Timothy D. McHugh and Norbert Heinrich on behalf of the Pan African Consortium for the Evaluation of Anti-tuberculosis Antibiotics (PanACEA)

J. Clin. Microbiol. August 2014 vol. 52 no. 8 3064-3067
Published May 2014
DOI: 10.1128/JCM.01128-14
Link to publication: http://jcm.asm.org/content/52/8/3064.full

We evaluated the use of the molecular bacterial load (MBL) assay, for measuring viable Mycobacterium tuberculosis in sputum, in comparison with solid agar and liquid culture. The MBL assay provides early information on the rate of decline in bacterial load and has technical advantages over culture in either form.


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